10 Best Cat Flea Medicines

After analyzing 251 products, scanning 1255 reviews, spending more than 36 hours of research and speaking with our test users, we think the Bayer Advantage II for Large Cats Over 9 lbs is the one of the Best Cat Flea Medicine on the market.

# Image Name Brand Price
1 Bayer Advantage II for Large Cats Over 9 lbs Bayer Advantage II for Large Cats Over 9 lbs, 6 Pack
(Editor’s Choice)
Bayer Animal Health $$$$$ Check price
2 Frontline Plus for Cats and Kittens (1.5 pounds and over) Frontline Plus for Cats and Kittens (1.5 pounds and over) Flea and Tick Treatment, 3 Doses Frontline $$$$$ Check price
3 Advecta II Flea Treatment for Cats over 9 lbs Advecta II Flea Treatment for Cats over 9 lbs, Flea Prevention for Cats, 4 Month Supply
(Best value for the money)
Advecta $$$$$ Check price
4 Capstar Flea Tablets for Dogs and Cats Capstar Flea Tablets for Dogs and Cats, 6 Count, 2-25 lbs, Blue Novartis $$$$$ Check price
5 Elanco Animal Health Cheristin for Cats Topical Flea Treatment and Elanco Animal Health Cheristin for Cats Topical Flea Treatment and Prevention – 6 Monthly Doses Elanco Animal Health $$$$$ Check price
6 PETARMOR Plus Flea & Tick Prevention for Cats with Fipronil PETARMOR Plus Flea & Tick Prevention for Cats with Fipronil (Over 1.5 Pounds), 6 Monthly Treatments PETARMOR $$$$$ Check price
7 Advantage II for Cats 5-9 Lbs~ 4 Months Advantage II for Cats 5-9 Lbs~ 4 Months Bayer Animal Health $$$$$ Check price
8 PETARMOR Flea & Tick Treatment for Cats with Fipronil (Over PETARMOR Flea & Tick Treatment for Cats with Fipronil (Over 1.5 Pounds), 3 Monthly Applications PETARMOR $$$$$ Check price
9 SENTRY Fiproguard Flea and Tick Topical for Cats SENTRY Fiproguard Flea and Tick Topical for Cats, 1.5 lbs and over, 6 Month Supply SENTRY Pet Care $$$$$ Check price
10 Advantage Once-A-Month Topical Flea Treatment for Cats Over 9 Lbs Advantage Once-A-Month Topical Flea Treatment for Cats Over 9 Lbs (4 Applications) Bayer Animal Health $$$$$ Check price

Bayer Advantage II for Large Cats Over 9 lbs – Best Overall Cat Flea Medicine

Bayer Advantage II for Large Cats Over 9 lbs
  • Veterinarian-recommended monthly flea treatment for cats;Kills reinfesting fleas within 2 hours
  • Odorless
  • Kills through contact. No biting required
  • Easy to apply flea prevention for cats
  • Starts working within 12 hours, keeps working for 30 days
  • Brought to you by Bayer
  • Packaging may vary

Frontline Plus for Cats and Kittens (1.5 pounds and over)

Frontline Plus for Cats and Kittens (1.5 pounds and over)
  • WATERPROOF FLEA AND TICK TREATMENT FOR CATS AND KITTENS: Frontline Plus for Cats provides waterproof, fast-acting, long-lasting flea and tick treatment and control for your cat.
  • This product is approved for use on cats and kittens 1.5 lbs and over.
  • BREAK THE FLEA LIFE CYCLE WITH FRONTLINE:
  • Frontline flea and tick treatment for cats kills adult fleas plus flea eggs and larvae to stop existing infestations and prevent establishment of new infestations.
  • KILLS FLEAS AND TICKS: Frontline flea and tick treatment for cats kills fleas, flea eggs, lice, and ticks.
  • This flea and tick treatment kills ticks, including those that may transmit Lyme disease
  • TRUSTED FLEA AND TICK PROTECTION FOR CATS: Frontline Plus for Cats has been trusted by veterinarians for nearly 20 years.
  • Made with 2 tough killing ingredients, fipronil and (S)-methoprene - one to kill adult fleas and ticks and the second to kill flea eggs and larvae - this fast-acting, long-lasting protection provides flea and tick control for cats and kittens 8 weeks and older.
  • LASTING FLEA AND TICK PROTECTION: Frontline's long-lasting formula is stored in the oil glands of the cat's skin to give non-stop flea and tick protection for a full 30 days.
  • Frontline flea and tick treatment for cats works non-stop for a full 30 days. A 3-dose supply lasts for 3 months.

Advecta II Flea Treatment for Cats over 9 lbs – Best Budget Cat Flea Medicine

Advecta II Flea Treatment for Cats over 9 lbs
  • BREAK THE FLEA LIFE CYCLE: Effectively breaks the flea life-cycle by killing all life stages of fleas: adults, eggs and larvae
  • ACTIVE INGREDIENTS THAT WORK: Contains the same active ingredients as Bayer Advantage II for Cats (pyriproxyfen & imidacloprid)
  • FLEA TREATMENT FOR CATS: Kills fleas within 12 hours of drops application, and prevents reinfestations for up to 4 months
  • CONVINEINT AND EASY TO USE: Advecta II Flea Treatment for Cats is an easy to apply topical solution for the prevention and treatment of fleas in cats.
  • WATERPROOF, FRAGRANCE-FREE FORMULA: Flea medication remains effective & provides protection even if your pet gets wet

Capstar Flea Tablets for Dogs and Cats

Capstar Flea Tablets for Dogs and Cats
  • KILL FLEAS FAST: Capstar flea tablets kill fleas on dogs within 4 hours of application of this flea tablet, and 6 hours for cats.
  • FLEA TREATEMENT SAFE FOR DOGS: A single dose of Capstar Flea Treatment Tablets should kill the adult fleas on your pet. If your pet gets re-infested with fleas, you can safely give another dose as often as once per day.
  • EASY TO ADMINISTER: To give Capstar Flea Tablets, place the pill directly in your pet's mouth or hide it in food. If you hide the pill in food, watch closely to make sure your pet swallows the pill. If you are not sure that your pet swallowed the pill, it is safe to give a second pill.
  • TREAT ALL HOUSEHOLD PETS WITH FLEA AND TICK TREATMENT: Treat all infested pets in the household. Fleas can reproduce on untreated pets and allow infestations to persist.
  • Almost all adult fleas will die
  • Fleas will die within 4 hours for dogs and 6 hours for cats
  • Single dose
  • Kills adult fleas
  • Works on dogs and cats, Item comes as a Single Box of 6 tablets

Elanco Animal Health Cheristin for Cats Topical Flea Treatment and

Elanco Animal Health Cheristin for Cats Topical Flea Treatment and
  • FLEA TREATMENT FOR CATS: A gentle one size-fits-all flea treatment. Great for multi-cat families, Cheristin kills fleas for fast, long-lasting protection
  • KILLS FLEAS FAST: Start killing fleas fast within 30 minutes of application and lasts a full month for cats and kittens 8 weeks of age or older and 1.8 lbs or greater
  • EFFECTIVE FLEA TREATMENT: Cheristin Flea Treatment for cats killed 100% of fleas within 12 hours in controlled study
  • EASY TO USE: Simple to use and dependably long-lasting, Cheristin Flea Treatment provides 99% flea control for a full month
  • QUICK DRYING FLEA AND PROTECTION FOR CATS: Easy to use applicator is in a quick-drying, non-greasy formula that is comfortable to apply for you and your cat

PETARMOR Plus Flea & Tick Prevention for Cats with Fipronil

PETARMOR Plus Flea & Tick Prevention for Cats with Fipronil
  • PetArmor Plus Flea & Tick Topical Prevention for Cats kills fleas, flea eggs, flea larvae, ticks, and chewing lice for up to 30 days after application
  • This vet-quality formula beg begins killing fleas & ticks within 24 hours and may take up to 48 hours
  • PetArmor Plus works by breaking the flea cycle, and killing flea eggs and larvae for up to 12 weeks
  • Flea and tick treatment comes with six (6) 0.017 fl. oz. waterproof topical applications
  • Flea and tick prevention for cats protects your furry family member from brown dog ticks, American dog ticks, lone star ticks, and deer ticks (which may transmit Lyme disease)

PETARMOR Flea & Tick Treatment for Cats with Fipronil (Over

PETARMOR Flea & Tick Treatment for Cats with Fipronil (Over
  • PetArmor Flea & Tick Topical for Cats kills adult fleas, ticks, and chewing lice
  • This vet-quality formula acts fast and starts killing adult fleas within 24 to 48 hours and ticks within 72 hours
  • PetArmor flea & tick treatment protects cats and kittens 8 weeks and older for up to 30 days after application and prevents infestations of adult fleas
  • Flea and tick treatment for cats comes with three (3) 0.017 fl. oz. waterproof topical applications
  • Flea and tick protection for cats protects your furry family member from brown dog ticks, American dog ticks, lone star ticks, and deer ticks (which may transmit Lyme disease)

SENTRY Fiproguard Flea and Tick Topical for Cats

SENTRY Fiproguard Flea and Tick Topical for Cats
  • Kill fleas; ticks; chewing lice
  • SENTRY FIPROGUARD contains the same active ingredient as Frontline Top Spot
  • Can be used on kittens eight weeks of age and older; One weight break for cats of all weights

Advantage Once-A-Month Topical Flea Treatment for Cats Over 9 Lbs

Advantage Once-A-Month Topical Flea Treatment for Cats Over 9 Lbs
  • Once-a-month topical flea treatment
  • Kills fleas before they lay eggs and flea larvae before they hatch
  • Safe for all cats 8 weeks and older, and more than 9 pounds
  • Prevents re-infestation for up to 4 weeks
  • Includes 4 convenient applications; please read all label information on delivery

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